PARKINSONS DISEASE LONG TERM DISORDER THE CENTRAL NERVOUS SYSTEM THE MOTOR SYSTEM SYMPTOMS GENERALLY COME ON OVER TIME THE DISEASE OBVIOUS SHAKING RIGIDITY SLOWNESS WALKING THINKING BEHAVIORAL PROBLEMS DEMENTIA COMMON ADVANCED STAGES DEPRESSION ANXIETY PEOPLE SLEEP EMOTION MOTOR COLLECTIVELY PARKINSONISM PARKINSONIAN SYNDROME CAUSE UNKNOWN BELIEVED INVOLVE GENETIC ENVIRONMENTAL FACTORS FAMILY MEMBER THEMSELF RISK EXPOSED CERTAIN PESTICIDE PRIOR HEAD INJURIES REDUCED TOBACCO SMOKER DRINK COFFEE DEATH CELLS SUBSTANTIA NIGRA REGION MIDBRAIN RESULTS ENOUGH DOPAMINE REASON CELL DEATH POORLY UNDERSTOOD PROTEIN S LEWY BODIES NEURON DIAGNOSIS CASES NEUROIMAGING USED TO RULE NO CURE INITIAL ANTIPARKINSON MEDICATION LEVODOPA DOPAMINE AGONIST ONCE LESS CONTINUE EFFECTIVE SAME TIME PRODUCE COMPLICATION MARKED MOVEMENTS DIET REHABILITATION EFFECTIVENESS IMPROVING SURGERY DEEP BRAIN STIMULATION REDUCE DRUGS EVIDENCE SLEEP DISTURBANCES EMOTIONAL PROBLEMS PRESENT DEATHS THE AGE PERCENT MALES SEEN YOUNG ONSET AVERAGE LIFE EXPECTANCY THE ENGLISH DOCTOR JAMES PARKINSON PUBLISHED DESCRIPTION ESSAY IN PUBLIC AWARENESS CAMPAIGNS WORLD PARKINSONS DAY THE BIRTHDAY TULIP SYMBOL PUBLICS AWARENESS THE CONDITION ACTOR FOX OLYMPIC CYCLIST DAVIS PHINNEY PROFESSIONAL BOXER MUHAMMAD ALI TERM SYNDROME WHOSE TREMOR STIFFNESS SLOWING POSTURAL INSTABILITY SYNDROMES DIVIDED SUBTYPES ORIGIN PRIMARY ACQUIRED HEREDITARY PARKINSON PLUS SYNDROME MULTIPLE SYSTEM DEGENERATION DEFINED MEANING EXTERNAL IDENTIFIABLE RECENT GENES RELATED THE DEFINITION OF SIMILAR COURSE THE PARKINSONS DISEASE TERMS FAMILIAL SPORADIC BE USED TO DIFFERENTIATE TRULY CLASSIFIED MOVEMENT DISORDER RISE COGNITIVE SLEEP PROBLEMS PARKINSON PLUS DISEASES MULTIPLE SYSTEM ATROPHY PROGRESSIVE SUPRANUCLEAR PALSY CORTICOBASAL DEGENERATION DEMENTIA WITH LEWY BODIES PATHOPHYSIOLOGY ABNORMAL ACCUMULATION PROTEIN THE BRAIN ALZHEIMERS TAU PROTEIN NEUROFIBRILLARY TANGLE PATHOLOGICAL OVERLAP TAUOPATHIES SYNUCLEINOPATHIES SYMPTOM FIND NEUROFIBRILLARY TANGLES BRAINS SUBSET THE RELATIONSHIP BETWEEN COMPLEX HAS TO PARTS CONTINUUM AUTONOMIC DYSFUNCTION NEUROPSYCHIATRIC PROBLEMS BEHAVIOR THOUGHT ALTERATIONS CARDINAL INDIVIDUALS DO NOT DEVELOP REST MAXIMAL LIMB GREATER EXTENT DISTAL APPEARS ARM BECOMING BILATERAL FREQUENCY HERTZ FEATURE THE INDEX FINGER THE HAND CONTACT THE THUMB PERFORM SIMILARITY THE MOVEMENT TECHNIQUE HYPOKINESIA CHARACTERISTIC THE WHOLE PLANNING INITIATION FINALLY EXECUTION SEQUENTIAL HINDERED BRADYKINESIA DISABLING THE EARLY PERFORMING DAILY FINE MOTOR CONTROL SEWING GETTING DRESSED EVALUATION HANDS NOT EQUAL FOR ALL ACTIVITY EMOTIONAL STATE TO THE POINT BARELY ABLE WALK RIDE SORT OF RESISTANCE CAUSED MUSCLE TONE CONTINUOUS CONTRACTION UNIFORM THE COMBINATION TONE JOINT PAIN PAIN EARLY STAGES ASYMMETRICAL AFFECT THE NECK SHOULDER MUSCLES THE FACE EXTREMITIES THE PROGRESSION OF BODY ABILITY LEADING BALANCE BONE FRACTURES INSTABILITY YOUNGER UP TO EXPERIENCE NUMBER SEVERITY SIGNS AND SYMPTOMS GAIT POSTURE FESTINATION SHUFFLING STEPS SPEECH SWALLOWING VOICE FACE EXPRESSION HANDWRITING THE RANGE POSSIBLE APPEAR RANGE MILD SOMETIMES INCREASE PREVALENCE DURATION COGNITIVE DEFICIT EXECUTIVE DYSFUNCTION COGNITIVE FLEXIBILITY ABSTRACT THINKING WORKING MEMORY RELEVANT INFORMATION ATTENTION PERCEPTION ESTIMATION COGNITIVE PROCESSING SPEED MEMORY LEARNED IMPROVEMENT RECALL AIDED EXAMPLE ASKED FACIAL RECOGNITION DRAWN PERSON SIX TIMES THE GENERAL QUALITY CAREGIVER HIGHER PROBABILITY NURSING HOME CARE MOOD COGNITIVE IMPAIRMENT APATHY FACIAL EXPRESSION STATE QUIET IMPULSE CONTROL BEHAVIORS MEDICATION CRAVING BINGE EATING HYPERSEXUALITY PATHOLOGICAL GAMBLING PSYCHOTIC HALLUCINATION DELUSION PRECIPITANT PHENOMENA THEREFORE INCREASING ADDITION MANIFEST DAYTIME DROWSINESS REM SLEEP SYSTEMATIC REVIEW SHOWS PATIENTS ALTERATIONS IN AUTONOMIC NERVOUS SYSTEM LEAD ORTHOSTATIC HYPOTENSION BLOOD PRESSURE SKIN EXCESSIVE SWEATING URINARY INCONTINENCE ALTERED SEXUAL FUNCTION CONSTIPATION DISCOMFORT ENDANGER VISION ABNORMALITIES BLINK OCULAR PURSUIT SACCADIC AUTOMATIC EYES SAME DIRECTION GAZE BLURRED DOUBLE VISION CHANGES SENSE OF SMELL SENSATION PARESTHESIA TINGLING NUMBNESS PROPORTION ATTRIBUTED FACTORS CAUSAL RELATIONSHIPS LIVING THE COUNTRY RURAL ENVIRONMENTS DRINKING WATER RISKS EXPOSURE AGENTS INSECTICIDES CHLORPYRIFOS ROTENONE PARAQUAT HERBICIDE AGENT ORANGE ZIRAM HEAVY METALS ISSUE TRADITIONALLY MUTATION MUTATIONS CODE PARKIN KINASE DARDARIN EXCEPTION ACCOUNT FOR ONLY MINORITY SNCA GLUCOCEREBROSIDASE RISK FACTORS GAUCHERS DISEASE ASSOCIATION SEARCH MUTATED ALLELE PENETRANCE POSITIVE THE ROLE GENE COMPONENT MISSENSE MUTATION SINGLE NUCLEOTIDE LOCUS MISSENSE MUTATIONS ON THE OTHER HAND ASYMPTOMATIC CARRIER NAME TAKEN BASQUE WORD IDENTIFIED FAMILIES ENGLAND THE NORTH ACCOUNTING FAMILY HISTORY PROOF CAUSATION INVOLVED FUNCTION LYSOSOME ORGANELLES DIGEST CELLULAR WASTE PRODUCTS BREAK DOWN BASAL GANGLIA GROUP BRAIN STRUCTURES INNERVATED AREAS VENTRAL THE PARS COMPACTA THE CELLS MACROSCOPIC CUT NEURONAL LOS