CAFFEINE,CENTRAL NERVOUS SYSTEM,CNS STIMULANT,METHYLXANTHINE,CLASS,WORLDS,CONSUMED,PSYCHOACTIVE DRUG,PSYCHOACTIVE SUBSTANCES,LEGAL,NEARLY,PARTS,THE WORLD,MECHANISMS OF ACTION,EXPLAIN,BLOCKS,THE ACTION,RECEPTOR,THE ONSET,DROWSINESS,CERTAIN,AUTONOMIC NERVOUS SYSTEM,BITTER,WHITE,CRYSTALLINE,PURINE,ALKALOID,CHEMICALLY,RELATED,ADENINE,GUANINE,BASES,DEOXYRIBONUCLEIC ACID,DNA,RIBONUCLEIC ACID,RNA,THE SEEDS,NUTS,LEAVES,NUMBER,PLANTS,NATIVE,SOUTH AMERICA,EAST ASIA,SURVIVAL,REPRODUCTIVE,BENEFITS,COFFEE BEAN,MISNOMER,THE SEED,COFFEA,BEVERAGES,INGESTED,PREVENT,IMPROVE,DRINKS,EXTRACTED,STEEPING,THE PLANT,PRODUCT,WATER,PROCESS,INFUSION,COFFEE,COLA,POPULAR,NORTH AMERICAN,ADULTS,DAILY,POSITIVE,NEGATIVE,HEALTH EFFECTS,BE USED TO,BRONCHOPULMONARY DYSPLASIA,APNEA OF PREMATURITY,CAFFEINE CITRATE,THE WHO,MODEL,ESSENTIAL MEDICINES,CONFER,MODEST,DISEASES,PARKINSONS DISEASE,CANCER,META ANALYSIS,CARDIOVASCULAR DISEASE,CORONARY ARTERY DISEASE,STROKE,LESS,CUPS,DECAFFEINATED COFFEE,PEOPLE,EXPERIENCE,SLEEP,DISRUPTION,EVENING,HOURS,SHOW,LITTLE,DISTURBANCE,EVIDENCE,RISK,PREGNANCY,EQUIVOCAL,AUTHORITIES,PREGNANT WOMEN,LIMIT,THE EQUIVALENT,PRODUCE,MILD,DRUG DEPENDENCE,WITHDRAWAL,SYMPTOMS,SLEEPINESS,HEADACHE,IRRITABILITY,STOPS,INTAKE,TOLERANCE,INCREASED BLOOD PRESSURE,HEART RATE,URINE,OUTPUT,CHRONIC,PRONOUNCED,DO NOT,CONSISTENT,CLASSIFIED,THE FOOD AND DRUG,ADMINISTRATION,GENERALLY RECOGNIZED AS SAFE,GRAS,TOXIC,GRAMS,ADULT,HIGHER,MILLIGRAMS,CUP OF COFFEE,BEAN,SEED,HOW IT,PERCOLATION,ESPRESSO,THUS,ORDINARY,REACH,LETHAL DOSE,PURE,AVAILABLE,DIETARY SUPPLEMENT,LETHAL,TABLESPOON,SIZED,PREMATURE INFANTS,PREVENTION,WEIGHT GAIN,THERAPY,REDUCE,CEREBRAL PALSY,LANGUAGE,COGNITIVE,DELAY,ON THE OTHER HAND,LONG TERM,SIDE EFFECTS,POSSIBLE,PRIMARY TREATMENT,ORTHOSTATIC HYPOTENSION,STIMULANT,USED TO,PHYSICAL,FATIGUE,WAKEFULNESS,FOCUS,GENERAL,BODY,COORDINATION,AMOUNT,PERSON TO PERSON,BODY SIZE,DEGREE,DESIRED,BEGIN,ONE HOUR,MODERATE,DOSE,THREE OR FOUR,IMPROVES,TASK,SLEEP DEPRIVATION,SHIFT WORKERS,FEWER,CAUSED,NORMAL,VARIABLE,LEARNING,MEMORY,GENERALLY,REACTION TIME,AROUSAL,CONCENTRATION,SYSTEMATIC REVIEW,CONCURRENT,THEANINE,PSYCHOACTIVE,PROMOTE,ALERTNESS,ATTENTION,TASK SWITCHING,THE FIRST HOUR,POST,PROVEN,ERGOGENIC AIDS,HUMANS,ATHLETIC,ENDURANCE,SPORTS,CONDITIONS,SPRINT,CYCLING,RUNNING TIME,TRIAL,DELAYS,MUSCLE FATIGUE,CENTRAL FATIGUE,POWER,HEALTH,CANADA,DEVELOPED,ADVICE,ADOLESCENTS,DATA,GROUP,NO MORE,BODY WEIGHT,MAXIMUM,LIGHT WEIGHT,YOUNGER,THE DAILY,CAUSE,ADVERSE,THE MAJORITY,ADOLESCENT,CONSUMERS,CONSERVATIVE,SUGGESTION,OLDER,ABLE,SUFFERING,ADVERSE EFFECTS,THE REST,THE GENERAL,POPULATION,HEALTHY,CHILDREN,FOR CHILDREN,AVERAGE,WEIGHTS,TRANSLATES,LIMITS,INCREASE,BLOOD PRESSURE,VASOCONSTRICTION,HIGH,ARTERIAL STIFFNESS,AFFECT,GASTROINTESTINAL MOTILITY,GASTRIC ACID,SECRETION,BASAL METABOLIC RATE,WOMEN,ACCELERATE,BONE LOSS,EQUIVALENT,NORMALLY,STANDARD,SERVINGS,SOFT DRINKS,APPEAR,ACTION,ACUTE,INGESTION,RESULTS,SHORT TERM,STIMULATION,INDIVIDUALS,PERIOD,DAYS,WEEKS,DIURESIS,EXCRETION,NATRIURESIS,SALINE,MEDIATED,PROXIMAL TUBULAR,ADENOSINE RECEPTOR,URINARY OUTPUT,DEHYDRATION,DEVELOP,WEAK,BRONCHODILATION,UP TO,ASTHMATICS,MINOR,WARRANT,PSYCHIATRIC DIAGNOSIS,COMMON,ANXIETY,SLEEP LATENCY,REDUCED,ANXIETY DISORDERS,LITERATURE REVIEW,PANIC DISORDERS,GREATER THAN,FOR SOME,SYMPTOMS OF DEPRESSION,SUICIDE RISK,CONGENITAL MALFORMATIONS,MISCARRIAGE,GROWTH RETARDATION,CONCLUSION,QUALITY,LIMITING,THE UK,FOOD STANDARDS AGENCY,SHOULD,PRUDENCE,LESS THAN,INSTANT COFFEE,ONE AND A HALF,FRESH,THE AMERICAN,CONGRESS,OBSTETRICIANS,GYNECOLOGISTS,SAFE,HARMFUL,HORMONAL,CHANGES,SLOW,METABOLIC,CLEARANCE,THE SYSTEM,CAUSING,LONGER,THE THIRD,TRIMESTER,GIVING BIRTH,LOW BIRTH WEIGHT,BABY,POTENTIAL,IMPACT,FEMALE FERTILITY,CIRCUMSTANCES,CAUTION,MODERATION,CASE,INFORMATION,CHILDBEARING,WHETHER,ADDICTIVE,DISORDER,DEPENDS,ADDICTION,DEFINED,DIAGNOSTIC,CLASSIFICATION OF,CAFFEINE ADDICTION,DIAGNOSTIC MODEL,STATE,ADDICTED,THEREFORE,DECREASE,EVEN THOUGH,RESEARCH,SUPPORT,UNDERLYING,BIOCHEMICAL,MECHANISM,THE REWARD,SYSTEM,ADDITION,CLAIMS,THE AMERICAN PSYCHIATRIC,ASSOCIATION,DIAGNOSIS,STUDY,CLINICALLY SIGNIFICANT,DISTRESS,IMPAIRMENT,INCREASINGLY,PHYSICAL DEPENDENCE,ABSTINENCE,PSYCHOLOGICAL DEPENDENCE,CAFFEINE DEPENDENCE,INVOLVE,DEPRESSED MOOD,STOMACH PAIN,JOINT PAIN,HEADACHES,EXPERIENCED,HALF,STOP,TWO DAYS,PUBLISHED,SUFFICIENT,ORDER,CREATE,CLINICAL SIGNIFICANCE,LISTS,EMERGING,SECTION,THE MANUAL,REGULAR,SPREAD,THE DAY,COMPLETE,CAFFEINATED,SOFT DRINK,CONTINUE,DRINKERS,APPARENTLY,GENE POLYMORPHISM,CAFFEINE WITHDRAWAL,PLAY,ROLES,EXAMPLE,HOMOZYGOUS,ALLELE,HETEROZYGOTE,CHANCE,FEELING,ADRENOCEPTORS,MENTAL FATIGUE,BETA ADRENOCEPTORS,RECEPTORS,GLYCOGENOLYSIS,SECRET,INSULIN,INTRAMUSCULARLY,TRANSPORT,GLUCOSE,MUSCLE,ACTIVITY,GENES,PEOPLES,MOOD SWINGS,DEPRESSION,LEVEL,REPORTED,PERCENTAGE,HOMOZYGOTES,ADRENERGIC RECEPTORS,ROLE,SYMPTOM,ALTERED,NOREPINEPHRINE,ADRENOCEPTOR,AGONIST,NEUROTRANSMISSION,ETIOLOGY,SEEN,FASTER,OPPORTUNITY,ADAPT,LOSS,OVERALL,RISKS,ENDOMETRIAL CANCER,COLORECTAL CANCER,CANCERS,HEAVY,BLADDER CANCER,ALZHEIMERS,DISEASE,