MODELING,BRAIN,TWO PHOTON MICROSCOPY,DEEP,JOURNAL,FRONTIERS,ARTICLE,OPEN,HTTPS,DOI ORG,TAHIR,SREEKANTH,KURA,CHENG,RAFAT,FREDERIC,SAVA,DAVID,TIAN,DEEP LEARNING,PAGES,ELECTRICAL AND COMPUTER,ENGINEERING,BOSTON,UNIVERSITY,BOSTON MA,BIOMEDICAL ENGINEERING,ENGINEERING INSTITUTE,COLE POLYTECHNIQUE DE,MONTREAL,MONTREAL QC CANADA,NEUROLOGICAL SCIENCES,PSYCHIATRY,HACETTEPE UNIVERSITY,ANKARA TURKEY,RADIOLOGY,MASSACHUSETTS GENERAL HOSPITAL,HARVARD MEDICAL SCHOOL,CHARLESTOWN,IMPACT,STATEMENT,SEGMENTATION,BLOOD VESSELS,BRAINS,APPLICATIONS,HEMODYNAMIC,ANALYSIS,DISEASE,DIAGNOSIS,HERE,DEVELOP,TECHNIQUE,ACCURATE,VASCULAR,REGIONS,MOUSE,ACQUIRED,MULTIPLE,THE TECHNIQUE,COMPUTATIONALLY EFFICIENT,THUS,IDEAL,SCALE,INTRODUCTION,STEP IN,EXISTING,LACK,ABILITY,GENERALIZE,DATA,IMAGING,SYSTEMS,COMPUTATIONALLY,WORK,LIMITATIONS,METHOD,ABLE,SEGMENT,FRAMEWORK,LOSS FUNCTION,BALANCED,BINARY,CROSS ENTROPY,LOSS,TOTAL VARIATION REGULARIZATION,OUTPUT,EFFECTIVENESS,EXPERIMENTALLY,IN VIVO,DIMENSIONS,UP TO,RESULTS,SUPERIOR,GENERALIZABILITY,TRAIN,MICROSCOPE,HIGH QUALITY,NETWORK,OVERALL,FASTER,COMPUTATION,TERMS,VOXELS,DEPTH,THE STATE OF THE ART,CONCLUSION,PAVES,THE WAY,FUTURE,MODELING AND ANALYSIS OF,HEMODYNAMIC RESPONSE,GREATER,SCALES,INACCESSIBLE,NEURAL,ACTIVATION,VITAL,TOOL,UNDERSTANDING,BRAIN FUNCTION,PATHOLOGIES,PARTICULAR,MEASURING,DYNAMICS,PROVED,THE EARLY,CRITICAL,CEREBROVASCULAR,NEUROLOGICAL DISORDERS,STROKE,ALZHEIMERS,TOOLS,MEASUREMENT,RELY,FUNCTIONAL IMAGING,TECHNIQUES,EXAMPLE,FUNCTIONAL MAGNETIC RESONANCE,FMRI,POSITIVE,EMISSION,TOMOGRAPHY,OPTICAL IMAGING,MATHEMATICAL MODELS,NEUROIMAGING,INSIGHT,RELATION,MEASURED,SIGNALS,UNDERLYING,PHYSIOLOGICAL,PARAMETERS,CEREBRAL BLOOD FLOW,OXYGEN CONSUMPTION,RATE,METABOLISM,TOPOLOGICAL,REPRESENTATION OF,THE BLOOD,GRAPH,NODES,CONNECTED,EDGES,GENERALLY,THE FIRST STEP,PROCESS,TASK,IN VIVO IMAGING,CURRENT,STATE OF THE ART,SUFFER,LIMITED,COMPUTATIONAL,SPEED,VOLUMETRIC,THE BRAIN,RAPID,CONTRAST,EFFECTIVE,BENEATH,SURFACE,ADDRESS,PRESENT,EFFECTIVELY,DEEPER,LABEL,TO EACH,VOXEL,INPUT,ANGIOGRAM,WHETHER,NOT IT,BLOOD VESSEL,DEALING,SCATTERING,BACKGROUND,FLUORESCENCE,SOURCES,NOISE,MOTION,ARTIFACT,CORRUPTION,PIAL,PACKED,NONTRIVIAL,PRESENCE,CHALLENGES,NUMBER,EMPLOYED,THE HESSIAN,MATRIX 12,TRACING,OPTIMALLY,ORIENTED,FLUX,GEOMETRIC FLOW,IN PRACTICE,QUALITY,RECENT,IMPROVEMENT,TRADITIONAL,PRESENTED,STUDY,HYBRID,DEEP NEURAL NETWORK,DEPTHS,LESS THAN,100M,HAFT,AL 10,MODEL,SIMILAR,SLOW,ONE MONTH,DATASET,CONSISTING OF,ARCHITECTURE,SEGMENTING,SLICES,PREVIOUS,WITH RESPECT TO,PERFORMED,GOOD,TRAINING DATA,ONCE,THE NETWORK,TRAINED,ORDER,AL 9,RECENTLY,UNSUPERVISED,ACTIVE,GENERALIZATION,CAPABILITY,SUFFERS,TRAINING,TIMES,HIGH,COMPUTATIONAL COST,INFORMATION,THE TASK,200M,THEREFORE,NEED,FAST,COPE,PROCESSING,NEEDS,NOVEL,CONTRIBUTION,FOLD,APPLICATION,TOTAL VARIATION,TV,SINGLE IMAGING,REGULARIZATION,TERM,PIECE,WISE,CONTINUITY,IMPROVES,THE NEED,TRANSFER LEARNING,DOMAIN,TRANSFER,GROUND TRUTH,PARTICULARLY,USEFUL,IN DEEP,ANNOTATION,HUMAN,THE GROUND TRUTH,PRONE,PENALTY,INHERENT,DENOISING,FOR ANY,PREPROCESSING,AIDS,HISTOGRAM,ARBITRARY,ADDITION,IMPROVE,THE NOVEL,LIGHTWEIGHT,ORDER OF MAGNITUDE,THE CURRENT,PERFORM,ENABLING,ILLUSTRATE,UNIQUE,VOLUME,SECONDS,EXTRACTION,THE BINARY,DEVELOPED,LAPLACIAN,FLOW DYNAMICS,SHOW,VOLUMES,HIGH SPEED,FACILITATE,FIELD OF RESEARCH,PUBLICLY AVAILABLE,GITHUB COM,CISL,SYSTEM,PIPELINE,FIGURE 1,MODULAR,TAKES,FINALLY,PREDICTION,SECTION,IMPORTANCE,PRIMARY,THIS NETWORK,EXPOSED,VESSEL,RECOVERY,IMAGES,MEASUREMENTS,SIGNAL,FIGURE,RED CIRCLE,PATCHES,SIZE,CONJUNCTION,FEED FORWARD,MANNER,C,BELOW,USED TO,ACQUIRE,ANGIOGRAPHIC,SPECIMEN,3D GRAPH,PAPER,DETAIL,WEIGHTS,COMPLETE,UNSEEN,VISUAL,ILLUMINATION,FOCUS,HIGHER,LASER,POWER,THE SURFACE,SHADOWS,UNDERNEATH,REGION,DETECTION,THE SIGNAL,RATIO,GOING,TISSUE,EVALUATE,APPROACH,COMPARE,PREDICTED,HESSIAN MATRIX,MATRIX,TUBULAR,STRUCTURES,FUNCTION,HESSIAN,EIGENVALUES,CLOSER,POORLY,DISTINGUISH,SLICE,BETTER THAN,CONTEXT,ADVANTAGE,VARIATION,IMPROVING,DEEP VESSELS,ACCOUNT,OVERLAP,EXHIBIT,RATIOS,CONDITIONS,DISCUSSED,IMPROVEMENTS,COMPREHENSIVE,METRICS,HOLISTICALLY,THE TEST,MAXIMUM,INTENSITY,PROJECTIONS,MIPS,PHYSICAL,DISCRETE,THE AXIS,RANGES,THE EFFECT,INCREASE,BACKGROUND NOISE,ALGORITHMS,ANALYZING,SENSITIVITY AND SPECIFICITY,PERCENTAGE,FOREGROUND,JACCARD INDEX,INTERSECTION,THE UNION,REPRESENTING,SIMILARITY,DICE,INDEX,CORRELATED,SHAPES,THE OBJECT,FACTOR,ILL,SUITED,DELIMITING,COMPLEX,BOUNDARIES,THE VOLUME,SMALLER,CAPILLARIES,BIASES,CLASS,THE OTHER,SENSITIVITY,INSENSITIVE,TRUE NEGATIVE,PREDICTIONS,INDICATIVE,ON THE OTHER HAND,SPECIFICITY,TRUE POSITIVE,NEGATIVE,ACCURACY,SUBJECT TO,TYPE,LABELS,THE REST,PROBLEM,PREVALENT,SHORTCOMINGS,CORRELATION,MATTHEWS CORRELATION,METRIC,MORPHOLOGICAL SIMILARITY,HAUSDORFF DISTANCE,LENGTH,VALUE,CLASSES,SCORE,OF 1,MEANS,PERFECT,UNCORRELATED,CLASSIFIER,AKIN,RANDOM,GUESSING,EXTENT,SUITABLE,VARIANT,OUTLIERS,DERIVE,IN 26,DEGREE,COINCIDENCE,TOTAL LENGTH,GOAL,COMPARISON,QUANTITATIVE,EVALUATION OF,TESTING,THE BEST,ROLE,REASONABLE TIME,POTENTIAL,FOR REAL,WE DO,F1 SCORE,ARGUABLY,INTERE