CLUSTERED REGULARLY,SHORT,PALINDROMIC,REPEATS,CRISPR,PRONOUNCED,PROKARYOTIC,DNA,SEQUENCES,REPETITION,SPACER DNA,PREVIOUS,BACTERIOPHAGE,VIRUS,PLASMID,CRISPR CAS SYSTEM,IMMUNE SYSTEM,RESISTANCE,FOREIGN,GENETIC,ELEMENTS,PRESENT,PLASMIDS,PHAGE,ACQUIRED IMMUNITY,RECOGNIZE,CUT,EXOGENOUS,MANNER,ANALOGOUS,RNA INTERFERENCE,EUKARYOTIC,ORGANISMS,SEQUENCED,BACTERIAL,GENOMES,ARCHAEA,NUCLEASE,GUIDE,RNAS,CELL,THE CELLS,GENOME,DESIRED,LOCATION,EXISTING,GENES,ONES,IN CONCERT,ENZYMES,GENOME EDITING,GENE REGULATION,SPECIES,THE TREE OF LIFE,DISCOVERED,THE SYSTEM,FRANCISELLA NOVICIDA,SYSTEMS,THOUGHT,EXIST,BACTERIUM,RNA,SYSTEM,TARGETS,RATHER,CLEAVE,SINGLE STRANDED,KNOCK,DOWN,CRISPR INTERFERENCE,TECHNIQUE,POTENTIAL,APPLICATIONS,GERMLINE,HUMANS,ANIMALS,FOOD CROPS,CHOICE,BREAKTHROUGH OF THE YEAR,PROSPECT,BIOTECHNOLOGY,EDITING,HUMAN,UNIQUE,UNITS,ESCHERICHIA,COLI,OSAKA,UNIVERSITY,RESEARCHER,YOSHIZUMI ISHINO,THE ORGANIZATION OF,REPEATED SEQUENCES,ARRANGED,THE DNA,FUNCTION,INTERRUPTED,MICROBE,SPANISH,FRANCISCO,SPACED,SRSR,MICROBES,SUGGESTION,RELATED,ANALYSIS,PROTEIN SEQUENCES,ENCODED,THAT ONE,HELICASE,UNWOUND,ADAPTIVE IMMUNITY,INDEPENDENT RESEARCH,DERIVED,EXTRACHROMOSOMAL DNA,FRAGMENTS,VIRUSES,PREVIOUSLY,TRIED,ATTACK,THE CELL,THE SOURCE,SIGN,ROLE,BACTERIA,IDEA,REJECTED,HIGH PROFILE,JOURNALS,EVENTUALLY,PUBLISHED,RESEARCHERS,UNDERSTANDING,CRISPR CAS,INVOLVED,MICROBIAL,IMMUNITY,MECHANISM,MYSTERY,KOONIN,COLLEAGUES,PRODUCE,SMALL RNA,GUIDES,TARGET,VIRAL,EUKARYOTIC CELLS,HYPOTHESIZED,EXPERIMENTAL,WORK,REVEALED,FOOD INDUSTRY,SCIENTISTS,DANISCO,EVIDENCE,ADAPTIVE IMMUNE SYSTEM,REGION,STREPTOCOCCUS THERMOPHILUS,ACQUIRED,INFECTING,THE RESISTANCE,ADDING,WHOSE,SEQUENCE,MATCHED,PHAGES,TESTED,IDENTIFIED,COMPLEX,PROTEIN,SPACER,MOLECULES,BOUND,PROTEIN COMPLEX,STAPHYLOCOCCUS EPIDERMIDIS,PREVENT,CONJUGATION,FINDING,ODDS,PYROCOCCUS FURIOSUS,STUDY,DIRECT EVIDENCE,CUTS,STRANDS,JENNIFER DOUDNA,EMMANUELLE CHARPENTIER,SIMPLER,STREPTOCOCCUS PYOGENES,COMPONENT,ENGINEERED,FUSING,GUIDE RNA,MIXED,FIND,THE GUIDE,NUCLEOTIDE SEQUENCE,ARTIFICIAL,CLEAVAGE,TECHNOLOGICAL,ADVANCE,EDIT,FENG,GEORGE,CHURCH,SIMULTANEOUSLY,CULTURES,THE FIRST TIME,WIDE,RANGE,BAKERS YEAST,SACCHAROMYCES CEREVISIAE,ZEBRAFISH,FRUIT,FLIES,DROSOPHILA MELANOGASTER,AXOLOTL,NEMATODES,C,PLANTS,MICE,MONKEYS,HUMAN EMBRYOS,TRANSCRIPTION FACTORS,ACTIVATE,SILENCE,LIBRARIES,TENS,THOUSANDS,AVAILABLE,DIFFERENCES,CAUSING,CUT IN,DOUBLE STRANDED DNA,BLUNT,RICH,PROTOSPACER ADJACENT MOTIF,ALTERNATE,TARGETING,TRACRRNA,THE EARLY,DEVELOPED,ZINC FINGER NUCLEASE,SYNTHETIC,PROTEINS,DNA BINDING DOMAINS,CREATE,DOUBLE STRANDED,POINTS,TALEN,EASIER,BREAK,STRAND,ZINC FINGER NUCLEASES,TALENS,THE CREATION,CUSTOM,FOR EACH,DNA SEQUENCE,TIME CONSUMING,PROCESS,DESIGN,THE PROCESS,RNA SEQUENCE,SIZE,BASE PAIRS,SHOW,DYAD SYMMETRY,THE FORMATION OF,SECONDARY STRUCTURE,HAIRPIN,TRULY,SIMILAR,LENGTH,MATCH,PROKARYOTES,SELF,THE IMMUNE,RESPONSE,INFECTION,COMPARATIVE GENOMICS,MULTIPLE,INITIAL,ARCHAEAL,CAS GENE,FAMILIES,THE CURRENT,CLASSIFICATION,CLASSES,CLASS,NUCLEIC ACIDS,PURPOSE,DIVIDED,THE FIVE,SUBTYPES,TYPE,SIGNATURE,GENE,CATEGORY,COMPLEMENT,PHYLOGENY OF,GENERALLY,CLASSIFICATION SYSTEM,SHARE,COMPONENTS,SPORADIC,SUGGESTS,SUBJECT TO,HORIZONTAL GENE TRANSFER,EVOLUTION,NATURAL,NATURAL TRANSFORMATION,ENTER,INVADED,FIRST STAGE,CAPTURE,INSERT,LOCUS,IMMUNE SYSTEMS,ACQUISITION,MUTATION,CONFIRMED,HYPOTHESIS,SHOWING,IMMUNE,STRUCTURES,DIVERSE,AMINO ACID,CRYSTAL,PURIFIED,METAL,DEPENDENT,INTEGRASES,BIND,INDEPENDENT,REPRESENTATIVE,SSRNA,DSDNA,ENDORIBONUCLEASE,ACTIVITY,DIMER,BRIDGES,ENZYMATIC,SCAFFOLDING,BINDING,INTEGRATION,BIOINFORMATIC,REGIONS,RANDOMLY SELECTED,ADJACENT,DNA SEQUENCES,MAJOR,DIVISIONS,PAMS,TYPE II,TYPE III,POSITIONS,THE OTHER END,RULER,THUS,MAINTAINING,ARRAY,THE CONSERVATION,APPEARS,THE LEADER,SEQUENCE ANALYSIS,FIRST DIRECT,COPIED,DIRECT,INSERTION,NUCLEOTIDE,MACHINERY,LAST,POSITION,DIRECT REPEAT,APPEAR,DO NOT,LEVEL,CONSERVATION,BLUNT END,SULFOLOBUS SOLFATARICUS,CANONICAL MODEL,AS ONE,CAUSES,PHENOMENON,DETECTED,ALREADY,INTERACT,EACH OTHER,PRIMING,ALWAYS,CAUSED,OBSERVATION,SLIDES,THE TARGET,STEP,MUST,TRANSCRIPT,STEM,PAIRING,IDENTICAL,FLANK,LONGER,AT THE EDGE,PAIRED,LEAVING,WRAPPING,UPSTREAM,REPEAT SEQUENCE,LACK,FUNCTIONAL,ENCODE,EXTRA,COMPLEMENTARY,TRANS ACTIVATING CRRNA,TRANSCRIPTION OF,PRIMARY,RESULTS,BASE PAIRING,DSRNA,SUBSEQUENTLY,THE OTHER TWO,FULL,TRUNCATED,ASSOCIATE,RIBONUCLEOTIDE,PREFERENCE,CODING,NON CODING,INDICATIVE,TARGETING SYSTEM,CASCADE,STAGE,ANNEALING,SIGNALS,CONFORMATIONAL CHANGE,RELY,MULTIFUNCTIONAL,DUAL,RNASEH,DOMAINS,BASEPAIRING,THE OPPOSITE,SEVEN,MRNA,DNA GENOME,DISTINGUISHING,THEREFORE,COMMON,MATURATION,ENDS,CHROMOSOME,BEYOND,CLASSIFIED,RESTRICTION ENZYMES,MODEL,DRIVING,MUTATE,DIVERSITY,HOST,POPULATIONS,FIGHT,THE SEQUENCE,CONTINUE,HOSTS,POINT MUTATIONS,BACTERIAL STRAIN,REMAINS,SENSITIVE,STRAINS,RATES,EVOLVE,PHYLOGENETIC,RELATIONSHIPS,TO BE DETERMINED,COMPARATIVE GENOMIC,MUCH MORE,THOUSAND,YEARS AGO,METAGENOMIC,ACID MINE DRAINAGE,BIOFILM,VERSUS,THE OTHER,HIGHER,PREVALENCE,COMMUNITY,ORAL CAVITY,DETERMINED,MONTHS,LESS THAN,INDI